Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity

Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity

JJ Adams, S Narayanan, ME Birnbaum, SS Sidhu… - Nature …, 2016 - nature.com

The T cell antigen receptor (TCR)–peptide–major histocompatibility complex (MHC)
interface is composed of conserved and diverse regions, yet the relative contribution of each
in shaping recognition by T cells remains unclear. Here we isolated cross-reactive peptides …

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