2019年1月14日星期一

GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure

GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure

M Kim, MJ Platt, T Shibasaki, SE Quaggin, PH Backx… - Nature medicine, 2013 - nature.com
Abstract Glucagon-like peptide-1 receptor (GLP-1R) agonists exert antihypertensive actions
through incompletely understood mechanisms. Here we demonstrate that cardiac Glp1r
expression is localized to cardiac atria and that GLP-1R activation promotes the secretion of …


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