[HTML] Directed evolution of a gatekeeper domain in nonribosomal peptide synthesis

[HTML] Directed evolution of a gatekeeper domain in nonribosomal peptide synthesis

B Villiers, F Hollfelder - Chemistry & biology, 2011 - Elsevier

Modular natural products are biosynthesized by series of enzymes that activate, assemble,
and process a nascent chain of building blocks. Adenylation domains are gatekeepers in
nonribosomal peptide biosynthesis, providing the entry point for assembly of typical peptide …

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