Optimized Fmoc solid‐phase synthesis of the cysteine‐rich peptide linaclotide

Optimized Fmoc solid‐phase synthesis of the cysteine‐rich peptide linaclotide

M Góngora‐Benítez, J Tulla‐Puche… - Peptide …, 2011 - Wiley Online Library

Linaclotide, a small 14‐mer peptide highly rich in cysteines, is currently in phase III clinical
trials for the treatment of gastrointestinal disorders. The challenge in the assembly of
linaclotide consists of achieving the correct and clean folding of its three disulfide bridges …

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