Long-term cardiac pro-B-type natriuretic peptide gene delivery prevents the development of hypertensive heart disease in spontaneously hypertensive rats
A Cataliotti, JM Tonne, D Bellavia, FL Martin… - Circulation, 2011 - Am Heart Assoc
Background—Diastolic dysfunction associated with high blood pressure (BP) leads to
cardiac remodeling and fibrosis and progression to congestive heart failure. B-type
natriuretic peptide (BNP) has BP-lowering, antifibrotic, and antihypertrophic properties …
cardiac remodeling and fibrosis and progression to congestive heart failure. B-type
natriuretic peptide (BNP) has BP-lowering, antifibrotic, and antihypertrophic properties …
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