[HTML] Peptide macrocyclization catalyzed by a prolyl oligopeptidase involved in α-amanitin biosynthesis

[HTML] Peptide macrocyclization catalyzed by a prolyl oligopeptidase involved in α-amanitin biosynthesis

H Luo, SY Hong, RM Sgambelluri, E Angelos, X Li… - Chemistry & biology, 2014 - Elsevier

Amatoxins are ribosomally encoded and posttranslationally modified peptides that account
for the majority of fatal mushroom poisonings of humans. A representative amatoxin is the
bicyclic octapeptide α-amanitin, formed via head-to-tail macrocyclization, which is …

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