Product | PUMA Monoclonal Antibody |
Cat# | 100-2-125A |
Unit/Weight | 100 μg |
Unit Price | $311.00 |
Species Reactivity | H, M, R |
Tested Application(s) | E, WB |
Brief Description | p53 upregulated modulator of apoptosis |
Specific Description | Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. |
Storage | PUMA monoclonal antibody can be stored at 4°C, stable for one year. |
Peptide synthesis/Peptide Library Synthesis/Peptide Modification/Antibody Preparation Eve He eve@pepmic.com www.pepmic.com
2019年1月10日星期四
PUMA Monoclonal Antibody
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