Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u
C Chen, NS Malchus, B Hehn, W Stelzer… - The EMBO …, 2014 - emboj.embopress.org
Signal peptide peptidase (SPP) catalyzes intramembrane proteolysis of signal peptides at
the endoplasmic reticulum (ER), but has also been suggested to play a role in ER‐
associated degradation (ERAD). Here, we show that SPP forms a complex with the ERAD …
the endoplasmic reticulum (ER), but has also been suggested to play a role in ER‐
associated degradation (ERAD). Here, we show that SPP forms a complex with the ERAD …
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