MyD88 Monoclonal Antibody

Product	MyD88 Monoclonal Antibody
Cat#	100-15-22A
Unit/Weight	100 μg
Unit Price	$311.00
Species Reactivity	H, M
Tested Application(s)	E, WB, IHC
Brief Description	Myeloid differentiation primary response gene 88 antibody protect to plays an important role in the inflammatory response induced by cytokines IL-1
Specific Description	The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-kB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.
Storage	MyD88 monoclonal antibody can be stored at 4°C, stable for one year.