Isolation of a peptide containing d-amino acid residues that inhibits the α-helix-mediated p53–MDM2 interaction from a one-bead one-compound library

Isolation of a peptide containing d-amino acid residues that inhibits the α-helix-mediated p53–MDM2 interaction from a one-bead one-compound library

J Morimoto, Y Hosono, S Sando - Bioorganic & medicinal chemistry letters, 2018 - Elsevier

Abstract α-Helix-mediated protein–protein interactions (PPIs) are important targets in
biological research and drug development. Peptides containing d-amino acid residues are
attractive molecules for inhibiting α-helix-mediated PPIs because of their wide surface area …

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