… of receptor activity-modifying protein modulation of GPCR ligand selectivity through rational design of potent adrenomedullin and calcitonin gene-related peptide …

… of receptor activity-modifying protein modulation of GPCR ligand selectivity through rational design of potent adrenomedullin and calcitonin gene-related peptide …

JM Booe, ML Warner, AM Roehrkasse, DL Hay… - Molecular …, 2018 - ASPET

Binding of the vasodilator peptides adrenomedullin (AM) and calcitonin gene-related
peptide (CGRP) to the class B GPCR calcitonin receptor-like receptor (CLR) is modulated by
receptor activity-modifying proteins (RAMP). RAMP1 favors CGRP, whereas RAMP2 and …

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