The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system

The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system

S Gottesman, E Roche, YN Zhou… - Genes & …, 1998 - genesdev.cshlp.org

Interruption of translation in Escherichia coli can lead to the addition of an 11-residue
carboxy-terminal peptide tail to the nascent chain. This modification is mediated by SsrA
RNA (also called 10Sa RNA and tmRNA) and marks the tagged polypeptide for proteolysis …

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