Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of …

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of …

SW Barger, D Hörster, K Furukawa… - Proceedings of the …, 1995 - National Acad Sciences

In Alzheimer disease (AD) the amyloid beta-peptide (A beta) accumulates in plaques in the
brain. A beta can be neurotoxic by a mechanism involving induction of reactive oxygen
species (ROS) and elevation of intracellular free calcium levels ([Ca2+] i). In light of …

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