CaMK-II (Thr286) Antibody

Product	CaMK-II (Thr286) Antibody
Cat#	100-32-78A
Unit/Weight	100 μg
Unit Price	$381.00
Species Reactivity	H, M, X
Tested Application(s)	E, WB
Brief Description	Rabbit Polyclonal Antibody, Phosphospecific Antibody
Specific Description	CaM Kinase 2 alpha (CAMKII alpha) is a prominent Ser/Thr kinase in the central nervous system that functions in long-term potentiation and neurotransmitter release. A member of the NMDAR signaling complex at the excitatory synapse, it regulates NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. CAMK2a is composed of alpha, beta, gamma, and delta chains that assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. CaMK2a interacts with BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1. Phosphorylation of Thr286 produces an autonomously active form of CaM Kinase II. Autophosphorylation of Thr305 inhibits the activity CaM Kinase II.
Storage	Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.