2018年11月21日星期三

Chemically synthesized histone H2A Lys13 di-ubiquitination promotes binding of 53BP1 to nucleosomes

Chemically synthesized histone H2A Lys13 di-ubiquitination promotes binding of 53BP1 to nucleosomes

JB Li, YK Qi, QQ He, HS Ai, S Liu, JX Wang, JS Zheng… - Cell research, 2018 - nature.com
… Its sequence was divided into five segments, namely 1, 2, 3, 4 and 5. These segments were
assembled through a convergent strategy, and auxiliary-mediated ligation of peptide hydrazide
was applied to achieve site-specific ubiquitination (Supplementary information, Figures S1 …


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