Product | Connexin-43 (Ser368) Antibody |
Cat# | 100-32-75A |
Unit/Weight | 100 μg |
Unit Price | $381.00 |
Species Reactivity | B, D, Ck, G, H, M, Zf |
Tested Application(s) | E, WB |
Brief Description | Rabbit Polyclonal Antibody, Phosphospecific Antibody |
Specific Description | Connexin-43 (Gap junction alpha-1 protein, GJA1) forms connexons at cell gap junctions through which materials of low MW diffuse from one cell to a neighboring cell. Connexin-43 has a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Connexons are composed of a hexamer of connexins. Connexin-43 is expressed in the heart and fetal cochlear. Phosphorylation of Ser368 by PKC induces a conformational change of connexin-43 that results in a decrease in gap junction permeability. Defects in connexin-43 are the cause of autosomal dominant oculodentodigital dysplasia (ODDD), a serious condition of cranofacial anomalies, ocular defects and sometimes deafness and cardiac abnormalities. |
Storage | Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
Peptide synthesis/Peptide Library Synthesis/Peptide Modification/Antibody Preparation Eve He eve@pepmic.com www.pepmic.com
2018年11月14日星期三
Connexin-43 (Ser368) Antibody
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