[HTML] Deacylation mechanism by SIRT2 revealed in the 1′-SH-2′-O-myristoyl intermediate structure
Y Wang, YME Fung, W Zhang, B He, MWH Chung… - Cell chemical …, 2017 - Elsevier
… Highlights. • The structure of SIRT2 in complex with a thiomyristoyl lysine peptide inhibitor and
NAD is obtained. • … From intermediate II to the products, it is generally thought that water directly
attacks intermediate II, leading to the release of the deacylated peptide …
NAD is obtained. • … From intermediate II to the products, it is generally thought that water directly
attacks intermediate II, leading to the release of the deacylated peptide …
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