Indoxyl sulphate activates cardiac fibroblasts with enhanced collagen synthesis, upregulated angiotensin-neprilysin system, and paracrine induction of cardiomyocyte …

Indoxyl sulphate activates cardiac fibroblasts with enhanced collagen synthesis, upregulated angiotensin-neprilysin system, and paracrine induction of cardiomyocyte …

C Barisone, E Lazzarini, C Ruggeri, S Garibaldi… - Vascular …, 2018 - Elsevier

… After incubating neonatal mouse ventricular cardiomyocytes (mNVCM) with the conditioned
medium of control or IS-treated Fib, β-myosin heavy chain (β-MHC) and atrial and B-type natriuretic
peptide expression was analyzed by RT-PCR and glycolysis by enzymatic assays …

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