Product | Phospho-CREB-1 (Ser133) Antibody |
Cat# | 100-32-30A |
Unit/Weight | 100 μg |
Unit Price | $273.00 |
Species Reactivity | H, M, R |
Tested Application(s) | E, WB, IHC |
Brief Description | Rabbit Polyclonal Antibody, Phosphospecific Antibody |
Specific Description | The ATF/CREB family consists of transcription factors that function through binding to the cAMP responsive element (CRE) palindromic octanucleotide, TGACCTCA, a sequence present in many viral and cellular promoters. The best characterized members of this gene family include CREB-1, CREB-2, ATF-1, ATF-2, ATF-3 and ATF-4. These transcription factors share highly-related COOH terminal leucine zipper dimerization and basic DNA binding but are highly divergent in their amino terminal domains. Although each of the ATF/CREB proteins bind CREs in their homodimeric form, in certain instances they also bind as heterodimers, both within the ATF/CREB family and with members of the AP-1 transcription factor family. It has recently been shown that protein kinase A-mediated CREB phosphorylation results in its binding to a 265-kDa nuclear protein designated CBP (CREB-binding protein), which represents a CREB co-activator. Phosphorylation of Ser-133 is key for CREB transcriptional activity. |
Storage | Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
Peptide synthesis/Peptide Library Synthesis/Peptide Modification/Antibody Preparation Eve He eve@pepmic.com www.pepmic.com
2018年11月13日星期二
Phospho-CREB-1 (Ser133) Antibody
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