2018年11月14日星期三

SnoopLigase Catalyzes Peptide–Peptide Locking and Enables Solid-Phase Conjugate Isolation

SnoopLigase Catalyzes PeptidePeptide Locking and Enables Solid-Phase Conjugate Isolation

CM Buldun, JX Jean, MR Bedford… - Journal of the American …, 2018 - ACS Publications
Simple, efficient reactions for connecting biological building-blocks open up many new
possibilities. Here we have designed SnoopLigase, a protein that catalyzes site-specific
transamidation, forming an isopeptide bond with more than 95% efficiency between two …


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