T cells specific for a TAP-independent self-peptide remain naïve in tumor-bearing mice and are fully exploitable for therapy

T cells specific for a TAP-independent self-peptide remain naïve in tumor-bearing mice and are fully exploitable for therapy

EM Doorduijn, M Sluijter, KA Marijt, BJ Querido… - …, 2018 - Taylor & Francis

Cancers frequently evade immune-recognition by lowering peptide: MHC-I complexes on
their cell surface. Limited peptide supply due to TAP-deficiency results in such MHC-Ilow
immune-escape variants. Previously, we reported on a category of TAP-independent self …

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