2019年1月17日星期四

Fmoc synthesis of peptide thioesters without post-chain-assembly manipulation

Fmoc synthesis of peptide thioesters without post-chain-assembly manipulation

JS Zheng, HN Chang, FL Wang… - Journal of the American …, 2011 - ACS Publications
An operationally simple method for the synthesis of peptide thioesters is developed using
standard Fmoc solid-phase peptide synthesis procedures. The method relies on the use of a
premade enamide-containing amino acid which, in the final TFA cleavage step, renders the …


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