Salicylaldehyde ester-induced chemoselective peptide ligations: enabling generation of natural peptidic linkages at the serine/threonine sites

Salicylaldehyde ester-induced chemoselective peptide ligations: enabling generation of natural peptidic linkages at the serine/threonine sites

X Li, HY Lam, Y Zhang, CK Chan - Organic letters, 2010 - ACS Publications

A serine/threonine-based chemoselective ligation method is described. It uses an O-
salicylaldehyde ester at the C-terminus, reacting with N-terminal serine or threonine to
realize peptide ligations. The utility of the O-salicylaldehyde ester enables the rapid coupling …

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