A peptide nucleic acid–nuclear localization signal fusion that mediates nuclear transport of DNA
LJ Brandén, AJ Mohamed, CIE Smith - Nature biotechnology, 1999 - nature.com
Abstract We have combined a peptide nucleic acid (PNA) with the SV40 core nuclear
localization signal (NLS), to create a bifunctional PNA–NLS peptide. The PNA–NLS peptide
increased the nuclear uptake of oligonucleotides and enhanced the transfection efficacy of
localization signal (NLS), to create a bifunctional PNA–NLS peptide. The PNA–NLS peptide
increased the nuclear uptake of oligonucleotides and enhanced the transfection efficacy of
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