Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid β-peptide: involvement of calcium and …
Q Guo, BL Sopher, K Furukawa, DG Pham… - Journal of …, 1997 - Soc Neuroscience
Abstract Most autosomal dominant inherited forms of early onset Alzheimer's disease (AD)
are caused by mutations in the presenilin-1 (PS-1) gene on chromosome 14. PS-1 is an
integral membrane protein with six to nine membrane-spanning domains and is expressed
are caused by mutations in the presenilin-1 (PS-1) gene on chromosome 14. PS-1 is an
integral membrane protein with six to nine membrane-spanning domains and is expressed
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