Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta …

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta …

R Göke, HC Fehmann, T Linn, H Schmidt… - Journal of Biological …, 1993 - ASBMB

Abstract Exendin-4 purified from Heloderma suspectum venom shows structural relationship
to the important incretin hormone glucagon-like peptide 1-(7-36)-amide (GLP-1). We
demonstrate that exendin-4 and truncated exendin-(9-39)-amide specifically interact with the

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