Elevations in the fasting serum proinsulin–to–C-peptide ratio precede the onset of type 1 diabetes
EK Sims, Z Chaudhry, R Watkins, F Syed, J Blum… - Diabetes …, 2016 - Am Diabetes Assoc
OBJECTIVE We tested whether an elevation in the serum proinsulin–to–C-peptide ratio (PI:
C), a biomarker of β-cell endoplasmic reticulum (ER) dysfunction, was associated with
progression to type 1 diabetes. RESEARCH DESIGN AND METHODS Fasting total PI and C …
C), a biomarker of β-cell endoplasmic reticulum (ER) dysfunction, was associated with
progression to type 1 diabetes. RESEARCH DESIGN AND METHODS Fasting total PI and C …
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