Monobactam formation in sulfazecin by a nonribosomal peptide synthetase thioesterase

Monobactam formation in sulfazecin by a nonribosomal peptide synthetase thioesterase

RA Oliver, R Li, CA Townsend - Nature chemical biology, 2018 - nature.com

The N-sulfonated monocyclic β-lactam ring characteristic of the monobactams confers
resistance to zinc metallo-β-lactamases and affords the most effective class to combat
carbapenem-resistant enterobacteria (CRE). Here we report unprecedented nonribosomal …

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