Unsupervised HLA peptidome deconvolution improves ligand prediction accuracy and predicts cooperative effects in peptide–HLA interactions

Unsupervised HLA peptidome deconvolution improves ligand prediction accuracy and predicts cooperative effects in peptide–HLA interactions

M Bassani-Sternberg, D Gfeller - The Journal of Immunology, 2016 - Am Assoc Immnol

Ag presentation on HLA molecules plays a central role in infectious diseases and tumor
immunology. To date, large-scale identification of (neo-) Ags from DNA sequencing data has
mainly relied on predictions. In parallel, mass spectrometry analysis of HLA peptidome is …

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