2018年11月19日星期一

N-Butylpyrrolidinone as Alternative Solvent for Solid-Phase Peptide Synthesis

N-Butylpyrrolidinone as Alternative Solvent for Solid-Phase Peptide Synthesis

J Lopez, S Pletscher, A Aemissegger… - … process research & …, 2018 - ACS Publications
By means of a systematic approach, several green solvent candidates were tested for their
feasibility to replace the reprotoxic dimethylformamide (DMF) as a solvent used in solid-
phase peptide synthesis (SPPS). According to the results presented in this paper, it is clear …


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