DC-SIGN Monoclonal Antibody

Product	DC-SIGN Monoclonal Antibody
Cat#	100-10-11A
Unit/Weight	100 μg
Unit Price	$311.00
Species Reactivity	H
Tested Application(s)	E, WB, IHC
Brief Description	Biosyn provided Dendritic cell-specific ICAM-3-grabbing nonintegrin 1 antibody to protect amplify the amount of virus and extend duration of viral infectivity
Specific Description	Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes (1), where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN (2). ICAM-3 is the natural ligand for DC-SIGN (3). A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently (4-8). DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR are known to exisit (8). The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.
Storage	DC-SIGN monoclonal antibody can be stored at 4°C, stable for one year.