[D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, small molecule synthetic peptide leptin mimetics, improve glycemic control in diet-induced obese (DIO) mice

[D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, small molecule synthetic peptide leptin mimetics, improve glycemic control in diet-induced obese (DIO) mice

A Wang, BM Anderson, ZM Novakovic, P Grasso - Peptides, 2018 - Elsevier

We have previously shown that following oral delivery in dodecyl maltoside (DDM),[D-Leu-4]-
OB3 and its myristic acid conjugate, MA-[D-Leu-4]-OB3, improved energy balance and
glucose homeostasis in genetically obese/diabetic mouse models. More recently, we have …

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