[HTML] Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids

[HTML] Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids

VG KrishnaKumar, A Paul, E Gazit, D Segal - Scientific reports, 2018 - nature.com

Intra-cellular tau protein tangles and extra-cellular β-amyloid plaques are hallmarks of
Alzheimer's disease (AD), characterized by the conversion of natively unfolded monomeric
protein/peptide into misfolded β-sheet rich aggregates. Therefore, inhibiting the aggregation …

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