Complexation of NAC-Derived Peptide Ligands with the C-Terminus of α-Synuclein Accelerates Its Aggregation

Complexation of NAC-Derived Peptide Ligands with the C-Terminus of α-Synuclein Accelerates Its Aggregation

NN Jha, S Ranganathan, R Kumar, S Mehra… - Biochemistry, 2018 - ACS Publications

Aggregation of α-synuclein (α-Syn) into neurotoxic oligomers and amyloid fibrils is
suggested to be the pathogenic mechanism for Parkinson's disease (PD). Recent studies
have indicated that oligomeric species of α-Syn are more cytotoxic than their mature fibrillar …

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