2018年6月29日星期五

AD‐Peptide ligand of Nicotine Acetylcholine Receptors for brain‐targeted drug delivery

AD‐Peptide ligand of Nicotine Acetylcholine Receptors for brain‐targeted drug delivery

X WeiC Zhan, Q Shen, W Fu, C Xie… - Angewandte Chemie …, 2015 - Wiley Online Library
Lysosomes of brain capillary endothelial cells are implicated in nicotine acetylcholine
receptor (nAChR)-mediated transcytosis and act as an enzymatic barrier for the transport of
peptide ligands to the brain. A D-peptide ligand of nAChRs (termed D CDX), which binds to …


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