2018年6月30日星期六

Liquid-crystalline ordering of antimicrobial peptide–DNA complexes controls TLR9 activation

Liquid-crystalline ordering of antimicrobial peptide–DNA complexes controls TLR9 activation

NW Schmidt, F Jin, R Lande, T CurkW XianC Lee… - Nature materials, 2015 - nature.com
Double-stranded DNA (dsDNA) can trigger the production of type I interferon (IFN) in
plasmacytoid dendritic cells (pDCs) by binding to endosomal Toll-like receptor-9 (TLR9; refs
1, 2, 3, 4, 5). It is also known that the formation of DNA–antimicrobial peptide complexes can …


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