[HTML] FACT disrupts nucleosome structure by binding H2A-H2B with conserved peptide motifs

[HTML] FACT disrupts nucleosome structure by binding H2A-H2B with conserved peptide motifs

DJ Kemble, LL McCullough, FG Whitby, T Formosa… - Molecular cell, 2015 - Elsevier

FACT, a heterodimer of Spt16 and Pob3, is an essential histone chaperone. We show that
the H2A-H2B binding activity that is central to FACT function resides in short acidic regions
near the C termini of each subunit. Mutations throughout these regions affect binding and …

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