2018年6月30日星期六

A type of auxiliary for native chemical peptide ligation beyond cysteine and glycine junctions

A type of auxiliary for native chemical peptide ligation beyond cysteine and glycine junctions

SF Loibl, Z Harpaz, O Seitz - Angewandte Chemie International …, 2015 - Wiley Online Library
Native chemical ligation enables the chemical synthesis of proteins. Previously, thiol-
containing auxiliary groups have been used to extend the reaction scope beyond N-terminal
cysteine residues. However, the N-benzyl-type auxiliaries used so far result in rather low …


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