The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex

The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex

AC Seefeldt, F Nguyen, S Antunes… - Nature Structural and …, 2015 - nature.com

The increasing prevalence of multidrug-resistant pathogenic bacteria is making current
antibiotics obsolete. Proline-rich antimicrobial peptides (PrAMPs) display potent activity
against Gram-negative bacteria and thus represent an avenue for antibiotic development …

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