Highly improved enzymatic peptide synthesis by using biphasic reactors

Highly improved enzymatic peptide synthesis by using biphasic reactors

A Bastida, RM Blanco, SG Zárate… - Biocatalysis and …, 2018 - Taylor & Francis

The synthesis of hydrophobic peptide as Leu-enkephalin derivatives (n-acetyl phenyl-l
leucinamide) from hydrophobic esters (N-acetyl phenylalanine methyl ester) plus a high
excess hydrophilic nucleophile (l-leucinamide) catalyzed by immobilized chymotrypsin (α …

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*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.

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*Peptide Salt: TFA, Desalt, Acetate, HCl.

*Peptide Purity: From crude to ＞99.5%.

*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.

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