Sustained persistence of IL2 signaling enhances the antitumor effect of peptide vaccines through T-cell expansion and preventing PD-1 inhibition

Sustained persistence of IL2 signaling enhances the antitumor effect of peptide vaccines through T-cell expansion and preventing PD-1 inhibition

H Sultan, T Kumai, VI Fesenkova, AE Fan, J Wu… - Cancer immunology …, 2018 - AACR

Peptide vaccines can be a successful and cost-effective way of generating T-cell responses
against defined tumor antigens, especially when combined with immune adjuvants such as
poly-IC. However, strong immune adjuvants can induce a collateral increase in numbers of …

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