2018年6月8日星期五

The chemical diversity and structure-based evolution of non-peptide CXCR4 antagonists with diverse therapeutic potential

The chemical diversity and structure-based evolution of non-peptide CXCR4 antagonists with diverse therapeutic potential

D Peng, B Cao, YJ Zhou, YQ Long - European journal of medicinal …, 2018 - Elsevier
The CXC chemokine receptor 4 (CXCR4) is a highly reserved G-protein coupled 7-
transmembrane (TM) chemokine receptor which consists of 352 amino acids. CXCR4 has
only one endogenous chemokine ligand of CXCL12, besides several other natural …


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