Topical intestinal aminoimidazole agonists of G-protein-coupled bile acid receptor 1 promote glucagon like peptide-1 secretion and improve glucose tolerance

Topical intestinal aminoimidazole agonists of G-protein-coupled bile acid receptor 1 promote glucagon like peptide-1 secretion and improve glucose tolerance

M Lasalle, V Hoguet, N Hennuyer… - Journal of Medicinal …, 2017 - ACS Publications

The role of the G-protein-coupled bile acid receptor TGR5 in various organs, tissues, and
cell types, specifically in intestinal endocrine L-cells and brown adipose tissue, has made it
a promising therapeutical target in several diseases, especially type-2 diabetes and …

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