2018年10月22日星期一

Peptide macrocyclization inspired by non-ribosomal imine natural products

Peptide macrocyclization inspired by non-ribosomal imine natural products

LR Malins, JN deGruyter, KJ Robbins… - Journal of the …, 2017 - ACS Publications
A thermodynamic approach to peptide macrocyclization inspired by the cyclization of non-
ribosomal peptide aldehydes is presented. The method provides access to structurally
diverse macrocycles by exploiting the reactivity of transient macrocyclic peptide imines …


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