A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

B Finan, B Yang, N Ottaway, DL Smiley, T Ma… - Nature medicine, 2015 - nature.com

We report the discovery of a new monomeric peptide that reduces body weight and diabetic
complications in rodent models of obesity by acting as an agonist at three key metabolically-
related peptide hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent …

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