2018年12月26日星期三

Lymph node stromal cells acquire peptide–MHCII complexes from dendritic cells and induce antigen-specific CD4+ T cell tolerance

Lymph node stromal cells acquire peptide–MHCII complexes from dendritic cells and induce antigen-specific CD4+ T cell tolerance

J Dubrot, FV Duraes, L Potin, F Capotosti… - Journal of …, 2014 - jem.rupress.org
Dendritic cells (DCs), and more recently lymph node stromal cells (LNSCs), have been
described to tolerize self-reactive CD8+ T cells in LNs. Although LNSCs express MHCII, it is
unknown whether they can also impact CD4+ T cell functions. We show that the promoter IV …


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