Human PAI-1

Product	Human PAI-1
Cat#	101-5-06A
Sequence	His-Tag sequence not included: VHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVA SVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDE ISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWV KTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFH KSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAP YEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPL ENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTA VIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
Unit/Weight	0.01 mg
Unit Price	$228.00
Description	Plasminogen Activator Inhibitor 1 (PAI-1) is a serine protease inhibitor which can exist either in an active inhibitory conformation or in an inactive or latent conformation. PAI-1 is produced mainly by the endothelium but is also secreted by other tissue types including adipose tissue. PAI-1 is the principal inhibitor of tissue plasminogen activator and urokinase, therefore inhibiting fibrinolysis. Increased levels of PAI-1 have been linked with various conditions including cardiovascular disease, thrombosis, insulin resistance and obesity. Recombinant PAI-1 comprises a 379 amino acid fragment (24-402) corresponding to the mature PAI-1 protein and is expressed in E. coli with an amino-terminal hexahistidine tag.
Molecular Weight	47.23 kDa
Purity	Purity > 95% as determined by reducing and non-reducing SDS-PAGE, Bradford assay, Western blot and ELISA
Storage	Store at -20°C. Product is guaranteed one year from the date of shipment.