2018年12月29日星期六

Histones: at the crossroads of peptide and protein chemistry

Histones: at the crossroads of peptide and protein chemistry

MM Müller, TW Muir - Chemical reviews, 2014 - ACS Publications
1. INTRODUCTION In eukaryotic cells, inheritable information is stored in a nucleoprotein
complex referred to as chromatin. 1 This genome architecture serves two key purposes. On
the one hand, wrapping DNA (approximately 145− 147 basepairs) twice around a spool …


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