A Left‐Handed Solution to Peptide Inhibition of the p53–MDM2 Interaction

A Left‐Handed Solution to Peptide Inhibition of the p53–MDM2 Interaction

M Liu, M Pazgier, C Li, W Yuan, C Li… - Angewandte Chemie …, 2010 - Wiley Online Library

Throwing tumors a left‐hook punch: The oncoprotein MDM2 negatively regulates the activity
and stability of the tumor suppressor protein p53, and is an important molecular target for
anticancer therapy. Mirror‐image phage display identified a high‐affinity d‐peptide ligand of …

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