CD52 (HI186) Antibody

Product	CD52 (HI186) Antibody
Cat#	100-26-28A
Unit/Weight	2 ml
Unit Price	$299.00
Species Reactivity	H
Tested Application(s)	FC
Brief Description	Mouse Monoclonal Antibody, FITC-conjugated Antibody
Specific Description	The CD52 (HI186) antibody recognizes a 25-29 kDa glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein typically expressed at high levels on thymocytes, lymphocytes, NK cells, monocytes/macrophages. CD52 is expressed at 2% on some granulocytes and epithelial cells of male reproductive tract, and also expressed at variable levels on the majority of lymphoid malignancies, but not on erythrocytes and platelets. A somatic defect in the synthesis of GPI anchors causes a lack of CD52 antigen on cell surface on lymphocytes from patients with paroxysmal nocturnal haemoglobinuria (PNH) . CD52 may be used to diagnose PNH besides CD55 and CD59. All CD52 antibodies are characterized by a strong lytic activity with human complement, irrespective of antibody isotype.
Storage	Store at 4°C. Product is guaranteed 6 months from the date of shipment.